Skip to Main Content

The University of Tennessee

Enter the name of your College, Department, or Unit Here

Frequently Used Tools:



 


Faculty Profile

Guoxun Chen

Guoxun Chen - click to enlarge

Education
B.S., Virology, 1986, Wuhan University, P.R. China

M.S., Virology, 1989, Wuhan University, P.R. China

Ph.D., 2001, Biochemistry and Molecular Biology, University of Texas Southwestern Medical Center at Dallas, USA.

Appointments
1986-1989: Graduate school, Department of Virology and Molecular Biology, Wuhan University, China.

1989-1995: Research Scientist, Institute of Virology, Hubei Academy of Medical Sciences, China.

1995-2001: Graduate school, Department of Biochemistry, Gifford Laboratories and Touchstone Center for Diabetes Research, UT Southwestern Medical Center.

2001-2006: Postdoctoral fellow, with Michael Brown and Joseph Goldstein, Department of Molecular Genetics, UT Southwestern Medical Center.

2006-present: Assistant Professor, Department of Nutrition, UT at Knoxville

Honors
1987 - 1988: Excellent Graduate Student of Wuhan University, Wuhan, China.

1986-1989: Graduate assistantship, Wuhan University, Wuhan, China.

1998: Outstanding scientific poster, Graduate Student Organization poster session, UT Southwestern Medical Center, Dallas, USA.

1999: Sigma-Xi, UT Southwestern Medical Center, Dallas, USA

1999-2001: NIH training grant award, UT Southwestern Medical Center, Dallas, USA.

Bibliography – Articles in Reviewed Journals
1. Chen G. Assaying of TGFs Produced by MA782/5s-8101 Mouse Mammary Tumor Cell Line. (1988) The Postgraduate Journal of Wuhan University. 1:93-95.

2. Chen, G. and Li, W.X., (1989) Studies of Cell Growth Stimulating Factors in Malignant Lung Adenocarcinoma Pleural Effusions. The Cancer Research on Prevention and Treatment, 16:200-202.

3. Yuan, X., Chen, G. and. Li, W.X., (1989) In Vitro Antitumor Action of Salvia Chinese Bent to Human Stomach and Oharyngeal Carcinoma Cells. Cancer Research on Prevention and Treatment, 16:7-9.

4. Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y.-T., O’Doherty, R., Newgard, C.B., and Unger, R.H., (1996) Disappearance of Body Fat in Normal Rats Induced by Adenovirus-Mediated Leptin Gene Therapy. Proc. Natl. Acad. Sci. USA. 93:14795-14799.

5. Koyama, K., Chen, G., Wang, M.-Y., Lee, Y.H., Shimabukuro, M., Newgard, C.B., and Unger, R.H.. (1997) ß-Cell Function in Normal Rats Made Chronically Hyperleptinemic by Adenovirus-Leptin Gene Therapy. Diabetes 46:1276-1280.

6. Shimabukuro, M., Koyama, K., Chen, G., Wang, M.-Y., Trieu, F., Lee, Y., Newgard, C.B., and Unger, RH. (1997) Direct Antidiabetic Effect of Leptin through Triglyceride Depletion of Tissue. Proc. Natl. Acad. Sci. USA 94:4637-4641.

7. Koyama, K., Chen, G., Lee, Y., and Unger, R.H.. (1997) Tissue Yriglycerides, Insulin Tesistance and Insulin Production: Implications for Hyperisulinemia of Obesity. Am. J. Physiol. 273:E708-E713.

8. Koyama, K., Shimabukuro, M., Chen, G., Wang, M.-Y., Lee, Y., Kalra, P.S., Dube, M.G., Kalra, S.P., Newgard, C.B., and Unger, R.H. (1998) Resistance to Adenovirally Induced Hyperleptinemia in Rats: Comparison of Ventromedial Hypothalamic Lesions With Mutated Leptin Receptors. J. Clin. Invest. 102:728-733.

9. Hohmeier, H., Mulder, H., Chen, G., Henkel-Reiger, R., Prentki, M., and Newgard, C.B. (2000) Isolation of INS-1-Derived Cell Lines With Robust KATP Channel-Dependent and -Independent Glucose-Stimulated Insulin Secretion. Diabetes 49:424-430.

10. Chen, G., Hohmeier, H., Gasa, R., Tran, V., and Newgard, C.B. (2000) Selection of Insulinoma Cell Lines With Resistance to IL-1ß and IFN-?-Induced Cytotoxicity. Diabetes: 49:562-570.

11. Chen, G., Hohmeier, H., and Newgard, C.B. (2001) Expression of the Transcription Factor STAT-1? in Insulinoma Cells Protects Against Cytotoxic Effects of Multiple Cytokines. J. Biol. Chem. 276: 766-772.

12. Yoon, J.C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Kahn, C.R., Granner, D.K., Newgard, C.B., and Spiegelman, B.M.. (2001) Control of Hepatic Gluconeogenesis Through the Transcriptional Coactivator PGC-1. Nature: 413:131-138.

13. Tran, V.V., Chen, G., Newgard, C.B., and Hohmeier, H.E. (2003) Discrete and complementary Mechanisms of Protection of Beta-Cells Against Cytokine-Induced and Oxidative Damage Achieved by bcl-2 Overexpression and a Cytokine Selection Strategy. Diabetes: 52:1423-1432.

14. Hohmeier, H.E., Tran, V.V., Chen, G., Gasa, R., and Newgard, C.B. (2003) Inflammatory Mechanisms in Diabetes: Lessons From the Beta-Cell. Int. J. Obesity & Related Metabolic Disorders 27: S12-6 (Suppl 3).

15. Newgard, C.B., Hohmeier, H.E., Lu, D., Jensen, M.V., Tran, V.V., Chen, G., Burgess, S., and Sherry, A.D. (2004) Understanding Basic Mechanisms of Beta-Cell Function and Survival: Prelude to New Diabetes Therapies. Cell Biochem. Biophys. 40:159-168 (3 Suppl).

16. Chen, G., Liang G., Ou J., Goldstein, J.L., and Brown, M.S. (2004) Central Role for Liver X Receptor in Insulin-Mediated Activation of Srebp-1c Transcription and Stimulation of Fatty Acid Synthesis in Liver. Proc. Natl. Acad. Sci. USA 101: 11245-11250.

Abstracts
1. Chen, G., Hohmeier, H.E., Tran, V.V., and Newgard, C.B. Selection of insulinoma cell lines resistant to cytokine-mediated cytotoxicity. 59th Scientific Session of American Diabetes Association, A239, June 19-22, 1999.

2. Chen, G., and Li, W. Studies of Tumor Cell Growth Stimulated by Malignant Lung Adenocarsinoma Pleural Effusions, Beijing International Conference on Biotechnology, 181, July 8-10, 1989.

 

Contact the Department of Nutrition

1215 W. Cumberland Ave.
229 Jessie Harris Building
Knoxville, TN 37996-1920

Brenda Hart
bhart57@utk.edu

Phone: (865) 974-5445
Fax: (865) 974-3491