Faculty Profile

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Michael Zemel
		865-974-6238 mzemel@utk.edu Professor Track: Nutrition Science

Academic Vita

Research Interests:

Obesity and metabolic disease. Regulation of adipocyte and muscle metabolism, with a focus on mitochondrial metabolism.  Alterations in calcium signaling which increase the
susceptibility to obesity, diabetes, and metabolic syndrome.

 

 

 

 

 

 

 

 

Michael B. Zemel, Ph.D.

Education
B.S. University of Wisconsin-Madison, 1976 Nutritional Sciences

M.S. University of Wisconsin-Madison, 1978 Nutritional Sciences

Ph.D. University of Wisconsin-Madison, 1980 Nutritional Sciences

 

Honors and Membership in Professional Organizations/Societies
American Heart Association (Fellow, Council on High Blood Pressure Research)

American Society for Clinical Nutrition

American Society for Nutritional Sciences

American College of Nutrition (Fellow)

North American Association for the Study of Obesity (Fellow)

Society for Experimental Biology and Medicine

Contributing Editor - Nutrition Reviews

Editorial Board - Journal of Nutritional Biochemistry

Research and Professional Experience
1994-Present Director, The Nutrition Institute
University of Tennessee, Knoxville, TN

1990-Present Professor of Nutrition and Medicine
University of Tennessee, Knoxville, TN

1990-2002 Department Head, Department of Nutrition
University of Tennessee, Knoxville, TN

1987-1991 Research Biochemist
VA Medical Center, Allen Park, MI

1985-1990 Associate Professor of Endocrinology/Hypertension
and Associate Professor of Nutrition and Food Science
Wayne State University, Detroit, MI

1980-1985 Assistant Professor of Nutrition and Food Science
Wayne State University, Detroit, MI

Bibliography (last five years 2003-2009)

Ha, E., and Zemel, M.B. (2003) Functional properties of whey, whey components, and essential amino acids:

Zemel, M. (2003) Calcium modulation of adiposity. Obesity Research 11:375-376.

Zemel, M.B. (2003) The metabolic shift: Role of dietary calcium and dairy products in modulating adiposity. Lipids 38:139-146.

Sun, X. and Zemel, M.B. (2003) Effects of mitochondrial uncoupling on adipocyte intracellular Ca2+ and lipid metabolism. J Nutr Biochem 14:219-226.

Zemel, M.B. (2003) Mechanisms of dairy modulation of adiposity. Journal of Nutrition 133:252S-256S.

Teegarden, D.T. and Zemel, M.B. (2003) Dairy product components and weight regulation. J Nutr 133:243S-244S.

Morris, K.L., Namey, T.C. and Zemel, M.B. (2003) Effects of dietary carbohydrate on the development of obesity in heterozygous Zucker rats. J Nutr Biochem 14:32-39.

Banz, W. J., Maher, M.A., Thompson, W.G., Bassett, D.R., Moore, W., Ashraf, M., Keefer, D.J., Zemel, M.B. (2003) Effects of resistance versus aerobic training on coronary artery disease risk. Exp Biol Med 228: 434-440.

Zemel, M.B. (2004) Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr 79:907s-912s.

Zemel, M.B. and Miller, S.L. (2004) Dietary calcium and dairy modulation of adiposity and obesity risk. Nutrition Rev 62:125-131.

Zemel, M.B., Thompson, W., Milstead, A., Morris, K., Campbell, P. (2004) Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obesity Research 12:582-590.

Sun X. and Zemel, M.B. (2004) Calcium and dairy inhibit weight and fat regain during ad libitum consumption following energy restriction in aP2-agouti transgenic mice. J Nutr 134:3054-3060

Sun X., and Zemel, M.B.  (2004) Role of uncoupling protein 2 (UCP2) expression and 1a, 25-Dihydroxyvitamin D3 in modulating adipocyte apoptosis.  FASEB J 2004; 18:130-1432 (Expanded version published on-line July 1, 2004: http://www.fasebj.org/cgi/doi/10.1096/fj.04-1971fje)

Melanson, E.L., Donahoo, W.T., Dong, F., Ida, T., and Zemel, M.B. (2005) Effect of low- and high-calcium dairy based diets on macronutrient oxidation in humans. Obesity Res 13:2102-2112.

Zemel MB. Role of dairy in weight management. (2005) J Am Coll Nutr (6 Suppl):537S-46S.

Thompson, W.G., Holdman, N.R., Janzow, D.J., Slezak, J.M., Morris, K.L. and Zemel, M.B.  (2005) Effect of energy-reduced diets high in dairy products and fiber on weight loss in obese adults. Obesity Res. 13:1344-1353.

Zemel, M.B., Richards, J., Milstead, A. and Campbell, P. (2005) Effects of calcium and dairy on body composition and weight loss in African-American adults. Obesity Res 13:1218-1225.

Zemel M.B. (2005) Calcium regulation of adiposity. Obesity Res 13:192-193.

Morris K.L. and Zemel, M.B. (2005) 1.25-dihydroxyvitamin D3 modulation of adipocyte glucocorticoid function. Obesity Res 13:670-677.

Zemel, M.B., Richards, J., Mathis S., Milstead A., Gebhardt L. and Silva E. (2005).  Dairy augmentation of total and central fat loss in obese subjects. Int J Obesity 29:391-397. 

Morris, K.L. and Zemel, M.B. (2005) Effect of dietary carbohydrate source on the development of obesity in agouti transgenic mice. Obesity Res 13:21-35

Sun, X.C. and Zemel, M.B.  (2006)  Dietary calcium regulates ROS production in aP2-agouti transgenic mice on high fat/high sucrose diets. Int J Obesity 30: 1341-1346.

Zemel, M.B. and Sun, X.C. (2007) Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells.  Lipids 42: 297-305

Sun, X.C. and Zemel, M.B. (2007) Calcium and 1,25-(OH)2-D3 regulation of adipokine expression in murine and human adipocytes and aP2-agouti transgenic mice.  Obesity 15:340-348.

Zemel, M.B. (2007) Dairy Foods, Calcium, and Weight Management.  In: Obesity: Epidemiology, Pathophysiology, and Prevention (pp. 477-493). CRC Press, Boca Raton, FL (B. Bagchi and H. Preuss eds.) 

Ding, S., McEntee, M.F., Whelan, J. and Zemel, M.B. (2007) Adiposity-Related Protection of Intestinal Tumorigenesis: Interaction with Dietary Calcium. Nutrition and Cancer 58(2):153-161.

Sun, X.C. and Zemel, M.B.  (2007)  1α, 25-dihydroxyvitamin D3 modulation of reactive oxygen species production and cell proliferation in human and murine adipocytes. Obesity 15:1944-1953.

Teegarden, D., White, K., Lyle, R.M., Zemel, M.B., Van Loan, M., Matkovic, V., Craig, B. and Schoeller, D. (2008) Calcium and Dairy Product Modulation of Lipid Utilization and Energy Expenditure.  Obesity 16:1566-1572.

Zemel M.B. and Sun, X. (2008) Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr 138:1047-1052.

Zemel, M.B. and Sun, X. (2008) Calcitriol and energy metabolism. Nutrition Reviews 66:s139-s146.

Major, G.C., Chaput, J-P, Ledoux, M., St-Pierre, S., Anderson, G.H., Zemel, M.B. and Tremblay, A.     (2008) Recent developments in calcium-related obesity research.  Obesity Reviews 2008;9:428-445.

Sun, X.C. and Zemel, M.B.  (2008) Calcitriol and calcium regulate cytokine production and adipocyte-macrophage cross-talk. J Nutr Biochem 19:392-399.

Zemel, M.B., Donnelly J.E., Smith B.K., Sulivan, D.K., Richards, J., Morgan-Hanusa, D., Mayo, M.S., Sun, X., Cook-Wiens, G., Bailey, B.W., Van Wallehen E.L. and Washburn, R.A. (2008) Effects of dairy intake onweight maintenance. Nutrition and Metabolism 5:28 (doi:10.1186/1743-7075-5-28).

Sun X. and Zemel M.B. (2008) 1,25-Dihydroxyvitamin D and corticosteroid regulate adipocyte nuclear vitamin D receptor. Int J Obesity 32:1305-1311.

Sun X., Morris .KL. and Zemel M.B. (2008) Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: A microarray study. J Nutrigenetics and Nutrigenomics 1:30-48.

Smilowitz, J.T., Wiest, M.M., Watkins, S.M., Teegarden, D., Zemel, M., German, B. and Van Loan, M.D. (2009) Lipid metabolism predicts changes in body composition during energy restriction in overweight individuals. J Nutr 139:222-229.

Kelishadi R, Zemel MB, Hashemipour M, Hosseini M and Mohammadifard N. (2009) Can a dairy-rich diet be effective in long-term weight control of young children? J Am Coll Nutr (in press).

Sun X and Zemel MB (2009) Leucine modulation of mitochondrial biogenesis and oxygen consumption in skeletal muscle cells and adipocytes. Nutrition and Metabolism 6:26

Zemel MB (2009) Proposed role of calcium and dairy food components in weight management and metabolic health. Physician Sport Med (in press)

Bruckbauer A, Guoffon J Rekapalli B and Zemel MB (2009) Effects of dairy components on energy partitioning and metabolic risk in mice: A microarray study. J Nutrigenet Nutrigenomics 2:64-77.

 

You can view Dr. Zemel's entire Community of Science profile here.

Contact the Department of Nutrition

1215 W. Cumberland Ave.
229 Jessie Harris Building
Knoxville, TN 37996-1920

Brenda Hart
bhart57@utk.edu

Phone: (865) 974-5445
Fax: (865) 974-3491