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Dr. Bettaieb and Lab staff

Ahmed Bettaieb’s Lab

Ahmed Bettaieb’s laboratory studies the molecular basis of metabolic diseases with a focus on obesity, type 2 diabetes, and their complications. The team investigates the metabolic and non-metabolic functions of key enzymes and signaling proteins, namely protein tyrosine phosphatases, protein kinases and hydrolases.

The long-term objectives are:
(1) Provide a better understanding of the molecular and genetic mechanisms contributing to the development of metabolic diseases.
(2) Exploit novel genes and therapeutic strategies aiming at reducing the overall burden of these diseases.

 Ahmed Bettaieb’s research history can be found here
His lab staff includes graduate research assistants, undergraduate volunteers, and lab technicians. A full directory can be found here.

1.Bettaieb, A. and D.A. Averill-Bates, Thermotolerance induced at a mild temperature of 40 degrees C protects cells against heat shock-induced apoptosis. J Cell Physiol, 2005. 205(1): p. 47-57.

2. Bettaieb, A. and D.A. Averill-Bates, Thermotolerance induced at a fever temperature of 40 degrees C protects cells against hyperthermia-induced apoptosis mediated by death receptor signalling. Biochem Cell Biol, 2008. 86(6): p. 521-38.

3. Wrzal, P.K., A. Bettaieb, and D.A. Averill-Bates, Molecular mechanisms of apoptosis activation by heat shock in multidrug-resistant Chinese hamster cells. Radiat Res, 2008. 170(4): p. 498-511.

4. Roy, J., et al., Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells. Chem Biol Interact, 2009. 181(2): p. 154-67.

5. Matsuo, K., et al., Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2. J Biol Chem, 2010. 285(51): p. 39750-8.

6. Roy, J., et al., Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: role of p53. Can J Physiol Pharmacol, 2010. 88(3): p. 353-68.

  1. Bettaieb, A., et al., Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase. J Biol Chem, 2011. 286(11): p. 9225-35.

  2. Bettaieb, A., et al., Adipose-specific deletion of Src homology phosphatase 2 does not significantly alter systemic glucose homeostasis. Metabolism, 2011. 60(8): p. 1193-201.

  3. Cummings, B.P., et al., Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats. Proc Natl Acad Sci U S A, 2011. 108(35): p. 14670-5.

  4. Luria, A., et al., Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. Proc Natl Acad Sci U S A, 2011. 108(22): p. 9038-43.

  5. Matsuo, K., et al., Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B. PLoS One, 2011. 6(1): p. e16446.

  6. Bettaieb, A., et al., Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2alpha signaling in brown adipocytes. PLoS One, 2012. 7(4): p. e34412.

  7. Cummings, B.P., et al., Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats. Endocrinology, 2012. 153(8): p. 3620-32.

  8. Inceoglu, B., et al., Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proc Natl Acad Sci U S A, 2012. 109(28): p. 11390-5.

  9. Nagata, N., et al., Hepatic Src homology phosphatase 2 regulates energy balance in mice. Endocrinology, 2012. 153(7): p. 3158-69.

  10. Vazquez-Prieto, M.A., et al., (-)-Epicatechin prevents TNFalpha-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes. Arch Biochem Biophys, 2012. 527(2): p. 113-8.

  11. Bakke, J., et al., Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B. Cell Commun Signal, 2013. 11: p. 57.

  12. Bettaieb, A., et al., Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. J Biol Chem, 2013. 288(24): p. 17360-71.

  13. Bettaieb, A., et al., Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. J Biol Chem, 2013. 288(20): p. 14189-99.

  14. Cummings, B.P., et al., Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats. Dis Model Mech, 2013. 6(2): p. 443-56.

  15. Lackey, D.E., et al., Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. Am J Physiol Endocrinol Metab, 2013. 304(11): p. E1175-87.

  16. Wang, Y.I., et al., Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress. PLoS One, 2013. 8(10): p. e78322.

  17. Bettaieb, A., et al., Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. PLoS One, 2014. 9(11): p. e113019.

  18. Bettaieb, A., et al., Soluble epoxide hydrolase deficiency ameliorates acute pancreatitis in mice. Free Radic Biol Med, 2014. 75 Suppl 1: p. S32.

  19. Bettaieb, A., et al., (-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress. Free Radic Biol Med, 2014. 72: p. 247-56.

  20. Bettaieb, A., et al., Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis. Cell Commun Signal, 2014. 12: p. 13.

  21. Cummings, B.P., et al., Administration of pioglitazone alone or with alogliptin delays diabetes onset in UCD-T2DM rats. J Endocrinol, 2014. 221(1): p. 133-44.

  22. Glory, A., A. Bettaieb, and D.A. Averill-Bates, Mild thermotolerance induced at 40 degrees C protects cells against hyperthermia-induced pro-apoptotic changes in Bcl-2 family proteins. Int J Hyperthermia, 2014. 30(7): p. 502-12.

  23. Liu, S., et al., Disruption of protein-tyrosine phosphatase 1B expression in the pancreas affects beta-cell function. Endocrinology, 2014. 155(9): p. 3329-38.

  24. Tanel, A., et al., Acrolein activates cell survival and apoptotic death responses involving the endoplasmic reticulum in A549 lung cells. Biochim Biophys Acta, 2014. 1843(5): p. 827-35.

  25. Tomilov, A., et al., Shc depletion stimulates brown fat activity in vivo and in vitro. Aging Cell, 2014. 13(6): p. 1049-58.

  26. Warden, C.H., et al., Brown Norway chromosome 1 congenic reduces symptoms of renal disease in fatty Zucker rats. PLoS One, 2014. 9(1): p. e87770.

  27. Bettaieb, A. and D.A. Averill-Bates, Thermotolerance induced at a mild temperature of 40 degrees C alleviates heat shock-induced ER stress and apoptosis in HeLa cells. Biochim Biophys Acta, 2015. 1853(1): p. 52-62.

  28. Bettaieb, A., et al., Soluble Epoxide Hydrolase Pharmacological Inhibition Ameliorates Experimental Acute Pancreatitis in Mice. Mol Pharmacol, 2015. 88(2): p. 281-90.

  29. Bettaieb, A., et al., Decreased adiposity and enhanced glucose tolerance in shikonin treated mice. Obesity (Silver Spring), 2015. 23(11): p. 2269-77.

  30. Bettaieb, A., et al., Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology, 2015. 149(2): p. 468-480 e10.

  31. Harris, T.R., et al., Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol, 2015.

  32. Inceoglu, B., et al., Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain. Proc Natl Acad Sci U S A, 2015. 112(29): p. 9082-7.

  33. Jialal, I., et al., Increased adipose tissue secretion of Fetuin-A, lipopolysaccharide-binding protein and high-mobility group box protein 1 in metabolic syndrome. Atherosclerosis, 2015. 241(1): p. 130-7.

  34. McGavigan, A.K., et al., TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice. Gut, 2015.

  35. Vazquez Prieto, M.A., et al., Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes. Mol Nutr Food Res, 2015. 59(4): p. 622-33.

  36. Xi, Y., et al., Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice. Diabetologia, 2015. 58(1): p. 122-31.

  37. Bettaieb, A., et al., Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol, 2016.

  38. Bettaieb, A., et al., Pancreatic Protein Tyrosine Phosphatase 1B Deficiency Exacerbates Acute Pancreatitis in Mice. Am J Pathol, 2016. 186(8): p. 2043-54.

  39. Cremonini, E., et al., (-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice. Arch Biochem Biophys, 2016. 599: p. 13-21.

  40. Sirish, P., et al., Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circ Arrhythm Electrophysiol, 2016. 9(5).

  41. Tomilov, A., et al., The mitochondrial isoform of Shc protein inhibits thiolase and lipid oxidation. J Biol Chem, 2016.

To learn more about Ahmed Bettaieb’s research, click here.