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Jiangang Chen, PhD- Lab

Jiangang Chen is an associate professor in both the Public Health and Nutrition Departments.

Chen researches potential environmental impacts on human reproduction, with a special interest in effects of endocrine disruptors (EDS) on the homeostasis of endogenous hormones. A considerable part of  his research has been focused on a wide variety of synthetic compounds with intrinsic hormonal activity that may have adverse effects on human health.

  1. 2001 Li, H.X., Nakajima, S.T., Chen, J., Todd, H.E., Overstreet, J.W., Lasley, B.L. Differences in Hormonal Characteristics of Conceptive versus Non-conceptive Menstrual Cycles. Fertility and Sterility: 75(3): 549-53.
  2. 2001 Shideler SE., Gee, NA., Chen, J., Lasley, BL. Estrogen and progesterone metabolites and follicle-stimulating hormone in the aged macaque female. Biol Reprod. 65(6):1718-25.
  3. 2001 Morán, FM., Tarara, R., Chen, J., Santos, S., Cheney, A., Overstreet, JW., Lasley, BL. Effect of dioxin on ovarian function in the cynomolgus macaque (M. fascicularis). ReprodToxicol. 15(4):377-83.
  4. 2001 Li, H., Chen, J., Overstreet, JW., Nakajima, ST., Lasley, BL. Urinary follicle-stimulatinghormone peak as a biomarker for estimating the day of ovulation. Fertil Steril. 77(5):961-6.
  5. 2001 Moran, F.M., Tarara, R., Chen, J., Santos, S., Cheney, A., Overstreet, J.W., Lasley, B.L. Effect of Dioxin on Ovarian Function in the Cynomolgus Macaque (M. Fascicularis). Reproductive Toxicology: 15(4): 377-83.
  6. 2002 Natarajan, K., Overstreet, JW., Rogers, JM., Denison, MS., Chen, J., Lohstroh, PN.,McConnell, DS., Lasley, BL. Detection of xenoestrogens in serum after immunoprecipitation of endogenous steroidal estrogens. EnvironHealth Perspect. 110(8):791-5.
  7. 2003 Shideler, SE., Gee, NA., Chen, J., Laughlin, LS., Rapp, PR., Morrison, JH., Roberts, JA., Moran, FM., Lasley, B.L Contribution of ovarian steroid production to urinary estrone conjugate concentrations in Macaca mulatta. Am J Primatol. 61(3):111-21.
  8. 2003 Chen, J., Qiu, Q., Lohstroh, PN., Overstreet, JW., Lasley, BL. Hormonal characteristics in the early luteal phase of conceptive and nonconceptive menstrual cycles. J SocGynecol Investig. 10(1):27-31.
  9. 2003 Moran, F.M., Lohstroh, P., VandeVoort, C.A., Chen, J., Overstreet, J.W., Conley, A.J., Lasley, B.L. Exogenous Steroid Substrate Modifies the Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on Estradiol Production of Human Lluteinized Granulosa Cells in vitro. Biology of Reproduction: 68(1): 244-51.
  10. 2003 Chen, J., Laughlin, L., Overstreet, J.W., Lasley, B.L. The Effect of 2,3,7,8-
    tetrachlorodibenzo-p-dioxin on Chorionic Gonadotropin (CG) Activity. Toxicology: 186(1-2): 21-31.
  11. 2003 Chen, J., Thirkill, T.L., Overstreet, J.W., Lasley, B.L., Douglas, G.C. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on Chorionic Gonadotropin (CG) Secretion by Human Trophoblasts. Reproductive Toxicology: 17(1): 87-93.
  12. 2003 Chen, J., Qiu, Q., Lohstroh, P., Overstreet, J.W., Lasley, B.L. Hormonal Characteristics in the Early Luteal Phase of Conceptive and Non-conceptive Menstrual Cycles. Journal of the Society for Gynecologic Investigation: 10(1): 27-31.
  13. 2003 Lohstroh, P.N., Chen, J., Ba, J., Ryan, L.M., Xu, X.P., Overstreet, J.W., Lasley, B.L. Bone Health Is Affected By Follicular Phase Length in Female Rotating Shift Workers. Environmental Health Perspectives: 111(4): 618-22. (contributed equally)
  14. 2003 Chen, J., Douglas, G.C., Thirkill, T.L., Lohstroh, P.N., Bielmeier, S.R., Narotsky, M.G., Best, D.S., Harrison, R.A., Natarajan, K., Pegram, R.A., Overstreet, J.W. and Lasley, B.L. Effect of Bromodichloromethane on Chorionic Gonadotrophin Secretion by Human Placental Trophoblast Cultures. Toxicological Sciences: 76(1): 75-82.
  15. 2004 Chen, J., Thirkill,T.L., Lohstroh, P.N., Bielmeier, S.R., Narotsky, M.G., Best, D.S., Harrison, R.A., Natarajan, K., Pegram, R.A., Overstreet, J.W., Lasley, B.L., Douglas, G.C. Bromodichloromethane Inhibits Human Placental Trophoblast Differentiation. Toxicological Sciences: 78(1): 166-74. Jiangang Chen, page 2
  16. 2006 Lohstroh, P., Dong, H., Chen, J., Gee, N., Xu, X., Lasley, B. Daily immunoactive and bioactive human chorionic gonadotropin profiles in periimplantation urine samples. BiolReprod. 2006 Jul;75(1):24-33.
  17. 2006 Chen, J., Sowers, M.R., Moran, F.M., McConnell, D.S., Gee, N.A., Greendale, G.A., Whitehead, C., Kasim-Karakas, S.E., Lasley, B.L. Circulating Bioactive Androgens in Midlife Women. Journal of Clinical Endocrinology and Metabolism: 91(11): 4387-94.
  18. 2007 Chen, J., Ahn, K.C., Gee, N.A., Gee, S.J., Hammock, B.D., Lasley, B.L. Antiandrogenic Properties of Parabens and Other Phenolic Containing Small Molecules in Personal Care Products. Toxicology And Applied Pharmacology: 221(3): 278-84.
  19. 2008 Yon, L., Chen, J., Moran, P., Lasley, B.L. An Analysis of the Androgens of Musth in the Asian Bull Elephant (Elephas maximus). General and Comparative Endocrinology:155(1):109-15.
  20. 2008 Chen, J., Ahn, K.C., Gee, N.A., Mohamed, M.I., Duleba, A.J., Zhao, L., Gee, S.J., Hammock, B.D., Lasley, B.L. Triclocarban Enhances Ttestosterone Action: A new Type of Endocrine Disruptor? Endocrinology 149(3):1173-9.
  21. 2008 Ahn, K.C., Zhao B., Chen, J., Cherednichenko, G., Sanmarti, E., Denison, M.S., Lasley, B., Pessah, IN., Kültz, D., Chang, D.P.Y., Gee, S.J., Hammock, B.D. In vitro Biologic Activities of the Antimicrobials Triclocarban, Iits Analogs, and Triclosan in Bioassay Screens: Rreceptor-based Bioassay Screens. Environmental Health Perspectives:116(9):1203-10.
  22. 2011 Duleba AJ, Ahmed MI, Sun M, Gao AC, Villanueva J, Conley AJ, Turgeon JL, Benirschke K, Gee NA, Chen J, Green PG, Lasley BL. Effects of triclocarban on intact immature male rat: augmentation of androgen action. Reproductive Sciences. 18(2):119-27.
  23. 2012 Lasley BL, Chen J, Stanczyk FZ, El Khoudary SR, Gee NA, Crawford S, McConnell DS. Androstenediol complements estrogenic bioactivity during the menopausal transition. Menopause. 19(6):650-657.
  24. 2012 Purohit J, Hu P, Chen J, Zhao L. The Effects of NOD Activation on Adipocyte Differentiation. Obesity in press
  25. 2013 Moran F.M, Chen J*, Lostroh P, Gee, N and Lasley B. Dehydroepiandrosterone sulfate (DHEAS) levels reflect endogenous LH production and respond to human chorionic gonadotropin (hCG) challenge in the older female macaque (Macacafascicularis).Menopause Menopause. 2013 20(3):329-35. * equal contribution
  26. 2013 Hu, P., Chen, X., Whitener, RJ., Boder, ET., Jones, JO., Porollo, A., Chen, J., Zhao, L. Effects of parabens on adipocyte differentiation. Toxicol Sci. 131(1):56-70.